比较铊的功效被活性炭吸附,普鲁士蓝,聚苯乙烯磺酸钠。
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霍夫曼RS,斯金格是的,范伯格RS, Goldfrank LR
比较铊的功效被活性炭吸附,普鲁士蓝,聚苯乙烯磺酸钠。
J Toxicol Toxicol。1999; 37 (7): 833 - 7。
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10630266 (在PubMed]
- 文摘
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背景:虽然普鲁士蓝是选择铊中毒的解毒剂,缺乏食品和药物管理局批准了制药配方导致寻找其他吸附剂。活性炭吸附铊体外已经证明,和铊和钾之间的相似性使得一些作者认为使用聚苯乙烯磺酸钠是一个潜在的吸附剂。这个实验的目的是比较相对铊绑定这些代理在一个标准的等温线模型的效果。方法:一个标准的醋酸铊缓冲溶液pH值7.0是激动与活性炭在25摄氏度,普鲁士蓝,或在吸附剂:聚苯乙烯磺酸钠铊100:1比率从1.5:1。为了进一步模拟生理条件下,所有的试验都重复在一个解决方案包含4更易与L磷酸钾。彻底搅拌后,混合物被允许定居和离心机,0.22微米过滤器过滤。浮在表面的铊含量通过原子吸收分光光度法测定。朗缪尔等温线是用来计算每个吸附剂的最大吸附容量,使用线性回归与皮尔森相关系数(r)。最大吸附能力比较p < 0.05被认为是重要的统计。结果:最大吸附能力定义为毫克每克吸附剂铊与线性回归p, r值(如图所示)如下:活性炭,59.7毫克/克(p = 0.005, r = 0.995);普鲁士蓝,72.7毫克/克(p = 0.004, r = 0.996); and sodium polystyrene sulfonate, 713 mg/g (p = 0.049, r = 0.951). All three values were statistically different from each other. At a physiologic potassium concentration, the maximal adsorptive capacities for activated charcoal and Prussian blue were essentially unchanged (58.3 mg/g and 69.8 mg/g, respectively, p > 0.05 for each vs trials without potassium), while the maximal adsorptive capacity for sodium polystyrene sulfonate fell to 39.1 mg/g (p = 0.003, r = 0.997, p = 0.005 vs sodium polystyrene sulfonate without potassium). CONCLUSIONS: This in vitro study confirms the utility of Prussian blue and activated charcoal as thallium adsorbents. Although sodium polystyrene sulfonate demonstrates exceptional in vitro adsorption of thallium, its greater affinity for potassium probably renders it clinically ineffective.