万:回顾其使用管理的骨关节炎,急性疼痛和风湿性关节炎。

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马西森AJ, Figgitt DP

万:回顾其使用管理的骨关节炎,急性疼痛和风湿性关节炎。

药。2001;61 (6):833 - 65。

PubMed ID

11398914 (在PubMed

]

文摘

万是一种选择性cyclo-oxygenase (COX) 2抑制剂有很少或没有影响COX-1同工酶在剂量1000毫克/天。万络比塞来昔布有更大的选择性cox - 2, meloxicam、双氯芬酸和吲哚美辛。在严格的临床试验,万500到12.5毫克/天已经评估了其功效治疗骨关节炎,急性疼痛和风湿性关节炎(低剂量125毫克/天(5)通常是用于慢性疼痛的迹象)。治疗骨关节炎的患者,万络比安慰剂更有效的提供缓解症状,扑热息痛(对乙酰氨基酚)和塞来昔布和布洛芬相似的功效,双氯芬酸、萘普生和nabumetone。总的来说,医生对疾病状态的评价和应对治疗的病人的评估往往对万络的支持。患者手术后的牙齿疼痛,疼痛在脊柱融合术或矫形手术,或原发性痛经,万络提供更快速、更持续的疼痛缓解和减少手术后要求补充使用吗啡比安慰剂。万络比塞来昔布更有效的患者脊柱融合手术后急性牙疼痛和痛苦,虽然塞来昔布可能已经开始在使用剂量。相比与传统的非甾体类抗炎药(非甾体抗炎药)布洛芬、双氯芬酸和萘普生钠,万络相似在急性疼痛的治疗效果。虽然萘普生钠提供快速缓解疼痛超过万络在原发性痛经患者,骨科手术后情况却相反:万络提供快速缓解疼痛,减少补充需要吗啡。万络和萘普生一样有效提供救助了8700类风湿性关节炎患者症状。 Compared with traditional NSAID therapy, rofecoxib had a significantly lower incidence of endoscopically confirmed gastroduodenal ulceration and, in approximately 13,000 patients with osteoarthritis and rheumatoid arthritis, a lower incidence of gastrointestinal (GI) adverse events. Rofecoxib was generally well tolerated in all indications with an overall tolerability profile similar to traditional NSAIDs. The most common adverse events in rofecoxib recipients were nausea, dizziness and headache. In conclusion, rofecoxib is at least as effective as traditional NSAID therapy in providing pain relief for both chronic and acute pain conditions. Rofecoxib provides an alternative treatment option to traditional NSAID therapy in the management of symptomatic pain relief in patients with osteoarthritis. Initial data from patients with primary dysmenorrhoea and postoperative pain are promising and further trials may confirm its place in the treatment of these indications. Rofecoxib has also shown promising results in patients with rheumatoid arthritis and is likely to become a valuable addition to current drug therapy for this patient population. Importantly, rofecoxib is associated with a lower incidence of GI adverse events than traditional NSAIDs making it a primary treatment option in patients at risk of developing GI complications or patients with chronic conditions requiring long term treatment.

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药物

万

药物靶点

药物	目标	类	生物	药理作用	行动
万	前列腺素合成酶2 G / H	蛋白质	人类	是的	抑制剂	细节